A Patient-Derived Xenograft Model of Glioblastoma
نویسندگان
چکیده
منابع مشابه
Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model
Adeno-associated virus (AAV) vectors expressing tumoricidal genes injected directly into brain tumors have shown some promise, however, invasive tumor cells are relatively unaffected. Systemic injection of AAV9 vectors provides widespread delivery to the brain and potentially the tumor/microenvironment. Here we assessed AAV9 for potential glioblastoma therapy using two different promoters drivi...
متن کاملThe Regression of Glioblastoma Multiforme is Time Dependent in Wild-Type Rat Xenograft Model
Introduction: Glioblastoma multiforme (GBM) is an aggressive case of primary brain cancer which remains among the most fatal tumors worldwide. Although, some in vitro and in vivo models have been developed for a better understanding of GBM behavior; a natural model of GBM would improve the efficiency of experimental models to human GBM tumors. We aimed at the present study to examine the surviv...
متن کاملDevelopment of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
Bone metastasis is a complex process that needs to be better understood in order to help clinicians prevent and treat it. Xenografts using patient-derived material (PDX) rather than cancer cell lines are a novel approach that guarantees more clinically realistic results. A primary culture of bone metastasis derived from a 67-year-old patient with breast cancer was cultured and then injected int...
متن کاملestablishment of autochthonous & standard cell line derived xenograft models of glioblastoma multiform in iran
background: gbm is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. several researchers around the world, including iran, have been investigated gbm-cell line in vitro. however in vivo studies have not been fulfilled. methods : as standard cell line (u-87mg) derived from human gbm and total gbm tumor derived from...
متن کاملErlotinib Inhibits Growth of a Patient-Derived Chordoma Xenograft
Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is surgery, often followed by radiotherapy. Treatment options for patients with recurrence are limited and, notably, there are no FDA approved therapeutic agents. Development of therapeutic options has been limited by the paucity of preclinical model systems. We have established and previously reported the i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: STAR Protocols
سال: 2020
ISSN: 2666-1667
DOI: 10.1016/j.xpro.2020.100179